An economic evaluation of voriconazole versus amphotericin B for the treatment of invasive aspergillosis in Canada
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چکیده
Health technology The study compared the use of voriconazole and conventional amphotericin B deoxycholate (CAB). Voriconazole was administered at a dose of 6 mg/kg intravenously (IV) twice a day on day 1, followed by 4 mg/kg IV twice a day for at least 7 days, at which time patients could switch to oral voriconazole 200 mg twice daily. CAB was administered at a dose of 1.0 to 1.5 mg/kg IV once a day.
منابع مشابه
An economic evaluation of voriconazole versus amphotericin B for the treatment of invasive aspergillosis in Canada.
BACKGROUND Invasive aspergillosis (IA) is a serious fungal infection that affects immunocompromised patients. The Global Comparative Aspergillosis study demonstrated that voriconazole, a new broad-spectrum triazole, had better responses and improved survival compared with conventional amphotericin B deoxycholate (CAB) and other licensed antifungal therapy (OLAT) for the treatment of definite or...
متن کاملEconomic evaluation of voriconazole in the treatment of invasive aspergillosis in the Netherlands.
OBJECTIVE To asses the cost-effectiveness of voriconazole in comparison to conventional amphotericin B and itraconazole for the treatment of invasive aspergillosis in the Netherlands. METHODS The cost-effectiveness of voriconazole in comparison to conventional amphotericin B or itraconazole was evaluated with a decision tree model followed by a life-time Markov model, focusing on long-term su...
متن کاملEconomic evaluation of voriconazole compared with conventional amphotericin B for the primary treatment of aspergillosis in immunocompromised patients.
OBJECTIVE The objective of this study was to conduct an economic evaluation of voriconazole compared with conventional amphotericin B deoxycholate (CAB) using data from a recently reported randomized comparative trial in patients with various underlying immunosuppressive conditions. This trial demonstrated the superiority of voriconazole in terms of clinical response, survival and safety when u...
متن کاملProphylaxis and treatment of invasive aspergillosis with voriconazole, posaconazole and caspofungin - review of the literature
Major progress for the management of invasive aspergillosis has come from the introduction of new antifungals since the late 1990s. Although mortality of invasive aspergillosis remains as high as 30-50%. Backbone of management are prophylaxis, early diagnosis and early initiation of antifungals for reduction of invasive aspergillosis related mortality. Randomized trials have been undertaken for...
متن کاملپروتکل استفاده از داروهای ضد قارچی در درمان عفونت های قارچی تهاجمی
Recently, despite the application of surgery and antifungal therapy, mortality rate of invasive fungal infections due to opportunistic fungi such as Candida and Aspergillus species has dramatically increased specially in immunocompromised host. The status of the immune system plays a key role in controlling the disease, yet antifungal therapy is of great benefit in saving involved patients. Tod...
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